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Malignant Tumors Of Liver Metastatic And NLS-diagnostics (Meta hunter)

Author:Biophilia  UpdateTime:2021-10-21
Diagnostics and treatment of malignant neoplasms are the most urgent issues in modern medicine. Oncologists face not only problems of primary and updating diagnostics of tumoral diseases, but also evaluation of various methods of tumor treatment efficiency, well-timed diagnosing of recurrent tumors after treatment procedures. Introduction of new three-dimensional technologies of NLS-pictures acquiring into clinical practice allows solving of abovementioned diagnostic problems at qualitatively new and higher level.  
 
Application of three-dimensional visualization of organs and tissues significantly extended potential of NLS-diagnostics. Today we may speak about truly early diagnostics of tumoral diseases at the first, pre-clinic stage of patient examination. Three-dimensional NLS-examination allows not only revealing of minimal structural changes in organs and tissues, but precise evaluating of tumoral process spreading extent, also, together with use of spectral-entropy analysis, it makes possible to identify diseases stage and choose adequate method of patient treatment.
 
In group of malignant tumors of liver metastatic invasion hold leading positions. It is well known that the most frequent reasons of liver metastatic disease are malignant tumors of large intestine, rectum, stomach, pancreas, mammary gland and lungs. At metastatic disease shape, structure, size of parenchyma and vascular pattern of liver are more or less changed, depending on duration of tumor existence, number and sizes of tumoral nodes. In addition to three-dimensional NLS-graphy, diverse variants of dopplerography, in the first place energy color mapping, may be used to solve problem of differential diagnostics of benign and malignant changes in liver parenchyma. Three-dimensional NLS-graphy method allows visualizing of three-dimensional picture of vessels location and form, marking them by certain color at the background of organ usual picture. In this aspect the method is rather close to x-ray angiography method and makes possible to visualize accurately great and minute vessels.  
 
Vascular pattern at single metastases is broken due to constriction and dislocation of hepatic branches certain vessels. At massive affection significant breach of vascular pattern happens. In some cases a therapist may detect local, chaotic change of vascular pattern, when hypervascularization of tumoral nodes is present. However tumoral nodes at liver metastatic disease may have both increased and deceased vascularization. Due to this fact data acquired with NLS-graphy is not always sufficient and should be completed with results of -ray angiography.
 
Differential diagnostics of tumoral affection of liver complicated by not only marked multiformity of changes, but also by its frequent combination with diffuse and dystrophic changes of organ’s parenchyma. All abovementioned stipulates necessity in wide application of spectral-entropy analysis of affection nidus. Our experience proves that availability of NLS-diagnostics equipment  Meta hunter makes possible detailed examination of three-dimensional hepatic neoplasms sized less that 3 mm. Therefore at early stage of pathology development a clinician is able to update morphological substrate of detected changes and to acquire sufficient information for diagnosis updating.  
 
It is well known that one of the leading methods of solitary hepatic metastases treatment is surgical operation. Proof of operation efficacy is the absence of metastases in other parts of liver. This problem may be successfully solved by three-dimensional NLS-ultramicroscopy with application of spectralentropy analysis. For a long time wide application of ultramisroscopic NLS-examination was limited by absence of special equipment with high resolution. Nowadays devices with super-high frequency nonlinear generator (40 GHz) are created, it makes possible to carry out three-dimensional ultramicroscopic revision and evaluation of chromosomal aberrations of almost any cell in human organism. Three-dimensional NLS-research may help to specify character, localization and number of pathological nidi when clinician plans liver resection because of metastatic disease. Our experience shows that application of three-dimensional NLS-graphy at cancer metastases of large intestine allows detection of additional nidi, not registered by any type of introscopy, in 20% of cases. Data acquired at three-dimensional NLS-graphy of liver makes possible to evaluate extent of operation, avoid unjustified surgical intervention and decrease risk of post-operative complications development.
 
Joint application of video-laparoscopy and NLS-research allows therapist to combine proper examination of abdominal organs and tissues with study of their structure by application of spectralentropy analysis in selected areas, and to carry out updating diagnostics of tumoral diseases of abdominal cavity organs and retroperitoneal space. At stomach cancer number of mistakes at pre-operation diagnostics of liver metastatic disease reaches 25% - 30%. The first application of such research technology proves that number of mistakes decreases to 3% - 5%.
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