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Metatron Hunter 4025 scan of brain tumor

Author:Biophilia  UpdateTime:2019-11-12

Metastasing of various tumors in brain strongly worsens the course of a disease. However modern treatment methods such as stereotactic radiosurgery and chemotherapy potential development provide substantial life prolongation of such patients. That is why well-timed, qualitative and which is more important quick overall assessment of oncological disease spreading is the key requirement for choosing of treatment method.

Positron emission tomography (PET) with the use of radiopharmaceutical 18-Fluorodeoxyglucose has high specificity and sensitivity, which means this method is the main method in assessment of disease spreading in oncological patients at the moment. In case of suspicion for brain metastatic affection, positron tomography of the whole body allows to reveal the primary nidus and to estimate disease spreading in organism in general. But, despite its advantages, this method has some essential restrictions that do not allow its using as a screening research. First of all, this is highly technical character of the method, production of radiopharmaceutical, its transportation and utilization demand additional staff except for medical personnel, another important aspect is relatively high cost of research. Long time of scanning, restrictions related with accompanying diseases (diabetes) also narrow down potentialities of this method.

Attempts to apply computer tomography (CT) and MRT of the whole body in search of primary tumoral centre and spread of oncological process have shown that the greatest informativity of these methods was achieved in visualization of bone damages and “non-mobile” parenchymatous organs. The problem of differential diagnostics of lymph nodes hyperplasia with tumoral affection (this fact is the criterion for assessment of a stage of disease) it is still unsolved now. Aside from that computer tomography and MRT in standard sequences demand duplicated scanning with contrast strengthening which considerably increases research time.

Three-dimensional nonlinear scanning (NLS) was included into clinical practice during last years, and at the present day it is frequently used in many areas of medicine. Main advantages of new 3D-NLS method, in our opinion, are: short research time (about 30 minutes) both high sensitivity and specificity.

The use of this method provides great possibility to “see” tumoral structures against the background of non-affected tissues due to their various chromogeneity.

The objective of this research is to evaluate possibilities of 3D-NLS of the whole body in assessment of tumoral process spread in patients with metastatic affection of brain.
3D NLS-research was performed with the use of “Metatron”-4025 system, The system is equipped with the digital trigger sensor, high-frequency generator (frequency 4,9 GHz) and continuous spiral scanning unit. Professional computer program «Metapathia GR Clinical» with possibility of three-dimensional visualisation, ultramicroscanning and spectral-entropic analysis is used together with the system.
Received axial NLS-images of body were processed on workstation with the use of multiplanar reconstruction algorithm, notably that color linear 6-point Fleindler’s scale was used for assessment of structures chromogeneity. 3D-model visually similar with received model at three-dimensional CT-research was rendered as a result. The assessment of received NLS was based on the analysis of localization and quantity of chromogeneity sites with high values which corresponded to the greatest tissue damage values. NLS-ultramicroscanning with spectral-entropic analysis was performed in all patients. Materials for carrying out of spectral-entropic analysis allowed assessment of specific expansive process according to the value of spectral similarity to pathologically altered tissues. In majority of patients the results of spectral-entropic analysis were histologically confirmed. In 90.3 % of cases the full confirmation of spectral-entropic analysis results by the data of histopathological examination was registered.

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